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Mauritius - Medical care and sickness benefit - Law, Act. Adoption : MUSL Creates a National Trust Fund for Community Health with the function of promoting primary health care activities with community participation, and to provide Health Centres and other public health institutions. Mauritius - Medical care and sickness benefit - Regulation, Decree, Ordinance. Government Notice No. Adoption : MUSR

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Acute lung injury ALI causes high mortality, but its molecular mechanisms are poorly understood. Acid aspiration is a frequent cause of ALI, leading to neutrophil sequestration, increased permeability, and deterioration of gas exchange. We investigated the role of platelet-neutrophil interactions in a murine model of acid-induced ALI.

Acid aspiration induced P-selectin—dependent platelet-neutrophil interactions in blood and in lung capillaries. Reducing circulating platelets or blocking P-selectin halted the development of ALI. Bone marrow chimeras showed that platelet, not endothelial, P-selectin was responsible for the injury. The interaction of platelets with neutrophils and endothelia was associated with TXA2 formation, with detrimental effects on permeability and tissue function.

Activated platelets induced endothelial expression of ICAM-1 and increased neutrophil adhesion. Inhibition of platelet-neutrophil aggregation improved gas exchange, reduced neutrophil recruitment and permeability, and prolonged survival. The key findings were confirmed in a sepsis-induced model of ALI. These findings may translate into improved clinical treatments for ALI.

Go to JCI Insight. Citations to this article. Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation. View: Text PDF. Research Article Pulmonology. Text PDF. Loading citation information Sign up for email alerts.

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Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation.

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Free to read. Acute lung injury ALI causes high mortality, but its molecular mechanisms are poorly understood.

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Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation

Acute lung injury ALI causes high mortality, but its molecular mechanisms are poorly understood. Acid aspiration is a frequent cause of ALI, leading to neutrophil sequestration, increased permeability, and deterioration of gas exchange. We investigated the role of platelet-neutrophil interactions in a murine model of acid-induced ALI. Acid aspiration induced P-selectin-dependent platelet-neutrophil interactions in blood and in lung capillaries. Reducing circulating platelets or blocking P-selectin halted the development of ALI. Bone marrow chimeras showed that platelet, not endothelial, P-selectin was responsible for the injury. The interaction of platelets with neutrophils and endothelia was associated with TXA 2 formation, with detrimental effects on permeability and tissue function.

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Invited to accede: 20 February Like most countries in the Latin-American region, Peru has not yet adopted a national cyber security strategy or policies related to countering cybercrime. Apart from the offenses contained under Law on Computer Crime , there are other substantive and procedural laws to investigate and prosecute crimes committed through the use of computer systems and information and communication technologies, which are the following:. The offenses related to the use of information and communication technologies that are sanctioned and punished under the current substantive law in Peru are the following:. The Law on Computer Crimes provides powers to public prosecutors, -pursuant to the urgency of the particular case and due diligence- to authorize the use of undercover agents in order to conduct investigations of the offenses provided in the law, as well as of every crime committed using information communication technologies. The Law on Computer Crimes gives the power to the National Police of Peru to establish communication mechanisms with the governing bodies of the Public Prosecutor and provide expertise in developing programs and actions for the proper prosecution of computer crimes and to develop programs for general protection and safety.

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