En ciertos casos es mas complicado determinar cuales han sido las causas que han desencadenado la cirrosis. Esta fase es irreversible. Lo mas importante es prevenirla no abusando en la ingesta de alcohol y previniendo las hepatitis B o C, dos de sus causas mas frecuentes. I was very happy to uncover this page.
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Liver fibrogenesis is the result of excessive tissue repair of chronic liver damage. This entity consists of the progressive extracellular matrix deposition in the liver parenchyma that is observed in most chronic liver diseases and which precedes the development of cirrhosis. In the last few years, several studies have identified activated stellate cells, portal fibroblasts, and myofibroblasts from distinct cell populations as the main collagen-producing cells in the damaged liver.
Likewise, the main cytokines and molecules involved in liver fibrogenesis have been identified. The finding that advanced liver fibrogenesis can be reversed has stimulated research into possible antifibrogenic therapies. Nevertheless, the only effective treatment is elimination of the causal agent.
The present article summarizes the progress made in the study of the pathogenesis of liver fibrogenesis and discusses the possible therapeutic targets for the development of antifibrogenic agents.. ISSN: Liver fibrogenesis: physiopathology. Descargar PDF. Autor para correspondencia. Palabras clave:. The present article summarizes the progress made in the study of the pathogenesis of liver fibrogenesis and discusses the possible therapeutic targets for the development of antifibrogenic agents.
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We report a case of a 63 year old male patient with history of chronic hepatopathy with cirrhosis. During his medical control and last hospitalization no cirrhosis etiology was found. On autopsy, excess iron was found with histochemical stains in liver, pancreas, myocardium and gastric mucosa. These findings, along with the clinical history and laboratory tests, showed that the origin of cirrhosis was primary hemochromatosis. Hepatic cirrosis , primary and secondary hemochromatosis , hemosiderosis , HME gene, transferrin , ferritin , serum iron, bronzed diabetes. Churchill Livingstone. USA : Elsevier.
Hyponatremia is the most common electrolyte disorder in patients with cirrhosis. In dilutional or hypervolemic hyponatremia, serum sodium concentration is reduced, plasma volume is increased although the effective plasma volume is decreased due to marked arterial vasodilation in the splanchnic circulation and extracellular fluid volume is increased, with ascites and edema in the absence of signs of dehydration. This is a result of the marked deterioration in renal excretion of solute-free water, leading to disproportionate water retention in relation to sodium retention. Since hypervolemic hyponatremia is by far the most frequent form of this disorder, the present chapter will concentrate specifically on hypervolemic hyponatremia in cirrhosis.. ISSN: