If you want to improve the formulation of pallets and beads in pharmaceutical industry, then try extruder Spheronizer. You can manufacture multi-particulates, such as beads and pellets, for an oral controlled drug delivery system. Gastrointestinal tract — Photo courtesy: University of Missouri. Extruder Spheronizer has wide use in the pelletization, granulation of spherical particles and granules. More particularly the sustained release oral solid dose types.
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Agglomeration through extrusion and spheronization is one of the oldest techniques for manufacturing pellets. The process consists of four process steps: Moistening the powder mixture, forming cylinder-shaped agglomerate through extrusion, breaking and rounding the extrudate to round pellets through spheronization, and drying the finished product.
The dry, mixed, powdery active substances are kneaded into a dough with a liquid. This dough then pressed through an extruder.
The diameter of the openings in the extrusion plate or extrusion basket determines the strength of the elongated extrusion threads that result. For technical reasons, the resulting pellets are larger than micrometers.
The ratio of liquid to solid material together with the size of the extruder holes significantly determines the quality of the extrudates. The final drying ensures the pellet hardness.
Even if the ball-shaped extrudate is imperfect, the evenness of the surface still creates good conditions for subsequent coating. For many pharmaceutical applications, extruded pellets are achieved in suitable quality if a sufficient portion of microcrystalline cellulose is added. In the pharmaceutical industry, pellets of medium particle sizes from to 2, micrometers are used for most applications.
In other industries, the size of the pellets can be several centimeters. Just the way you need it.
A Description of the Spheronization Process
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Extruder Spheronizer: The Ultimate Guide
Spheronization has many advantages link. The process is useful in several ways: it can improve the product; simplify manufacturing processes and help to reduce costs. The process is well known and widely used in the pharmaceutical industry but spheronization is becoming increasing recognized in other areas of industrial materials handling. The extrusion of the product is a required step prior to spheronization link. The size of the spheres are determined by the diameter of the extrudate used for the spheronization process. For example, in order to obtain spheres with a diameter of 1 mm, a 1 mm screen is used on the extruder, although spheres with a slighter bigger diameter will sometimes be obtained. In a spheronizer, it is possible to obtain spheres with a diameter ranging from about 0.
Extrusion / Spheronization
Capsugel has extensive experience and capabilities in optimizing pediatric and multiparticulate formulations. The technology chosen is dependent upon multiple active ingredient and formulation criteria, e. The process consists of five operations. The wet mass is added into an LCI Multigranulator MG 55 where it is forced through a specific screen to form cylindrical extrudates using either dome, radial or axial extrusion for process optimization. The wet extrudate is added to an LCI Marumerizer QJT spheronizer equipped with a high speed spinning plate which forms uniform spheres from the extrudate "rope". The resultant spheres are dried in a fluid bed dryer and particle size is selected by sieve cuts.