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A systematic review of oral fungal infections in patients receiving cancer therapy. Lalla, Rajesh V. The aims of this systematic review were to determine, in patients receiving cancer therapy, the prevalence of clinical oral fungal infection and fungal colonization, to determine the impact on quality of life and cost of care, and to review current management strategies for oral fungal infections. Comparison of efficacy of alternative medicine with allopathy in treatment of oral fungal infection. Directory of Open Access Journals Sweden.

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A systematic review of oral fungal infections in patients receiving cancer therapy. Lalla, Rajesh V. The aims of this systematic review were to determine, in patients receiving cancer therapy, the prevalence of clinical oral fungal infection and fungal colonization, to determine the impact on quality of life and cost of care, and to review current management strategies for oral fungal infections.

Comparison of efficacy of alternative medicine with allopathy in treatment of oral fungal infection. Directory of Open Access Journals Sweden. The study concluded that TTO, being a natural product, is a better nontoxic modality compared to clotrimazole, in the treatment of oral fungal infection and has a promising future for its potential application in oral health products.

Frequency of fungal infection in biopsies of oral mucosal lesions: A prospective hospital-based study. Full Text Available Aims and Objectives: To determine the frequency and common site of fungal infection in biopsies of oral mucosal lesions and also to detect the lesions most likely to be infected with fungal infection.

Materials and Methods: A total of patients with oral mucosal lesions were advised routine hematological examination followed by incisional biopsy under local anesthesia.

One section from the specimen was stained with hematoxylin and eosin staining for histopathological diagnosis of the lesion and a second section was stained with Periodic acid-Schiff PAS stain for detection of fungal infection. The maximum fungal positive association was encountered in the mucosal lesions over the tongue Conclusion: There is statistically significant association of fungal infection with dysplastic lesions and papilloma with the tongue and buccal mucosa as the most common sites.

Hence a PAS stain should be performed whenever epithelial dysplasia on the tongue and buccal mucosa is diagnosed. Full Text Available Peritonitis and exit-site infections are important complications in peritoneal dialysis PD patients that are occasionally caused by opportunistic fungi inhabiting distant body sites.

In this study, the oral yeast colonization of PD patients and the antifungal susceptibility profile of the isolated yeasts were accessed and correlated with fungal infection episodes in the following 4 years. PD patients presented a lower oral yeast prevalence when compared to controls, namely, Candida albicans.

Other species were also isolated, Candida glabrata and Candida carpophila. The antifungal susceptibility profiles of these isolates revealed resistance to itraconazole, variable susceptibility to caspofungin, and higher MIC values of posaconazole compared to previous reports.

The 4-year longitudinal evaluation of these patients revealed Candida parapsilosis and Candida zeylanoides as PD-related exit-site infectious agents, but no correlation was found with oral yeast colonization.

This pilot study suggests that oral yeast colonization may represent a limited risk for fungal infection development in PD patients. Oral yeast isolates presented a variable antifungal susceptibility profile, which may suggest resistance to some second-line drugs, highlighting the importance of antifungal susceptibility assessment in the clinical practice. Evaluating the potential of cubosomal nanoparticles for oral delivery of amphotericin B in treating fungal infection. The aim of this study was to investigate the potential of glyceryl monoolein GMO cubosomes as lipid nanocarriers to improve the oral efficacy of AmB.

Antifungal efficacy was determined in vivo in rats after oral administration, to investigate its therapeutic use. The human colon adenocarcinoma cell line Caco-2 was used in vitro to evaluate transport across a model of the intestinal barrier.

In the Caco-2 transport studies, GMO cubosomes resulted in a significantly larger amount of AmB being transported into Caco-2 cells, via both clathrin- and caveolae-mediated endocytosis, but not macropinocytosis. These results suggest that GMO cubosomes, as lipid nanovectors, could facilitate the oral delivery of AmB. Keywords: glyceryl monoolein cubosomes, oral delivery, amphotericin B, antifungal activity, absorption mechanism. Oral treatments for fungal infections of the skin of the foot.

There are many clinical presentations of tinea pedis, and most commonly, tinea pedis is seen between the toes interdigital and on the soles, heels, and sides of the foot plantar. Plantar tinea pedis is known as moccasin foot. Once acquired, the infection can spread to other sites including the nails, which can be a source of re- infection. Oral therapy is usually used for chronic conditions or when topical treatment has failed.

We checked the bibliographies of retrieved trials for further references to relevant trials, and we searched online trials registers. Selection criteria: Randomized controlled trials of oral treatments in participants who have a clinically diagnosed tinea pedis, confirmed by microscopy and growth of dermatophytes fungi in culture.

Data collection and analysis: Two review authors independently undertook study selection, "Risk of bias" assessment, and data extraction.

The 2 trials 71 participants comparing terbinafine and griseofulvin produced a pooled risk ratio RR of 2. No significant difference was detected between terbinafine and itraconazole, fluconazole and itraconazole, fluconazole and ketoconazole, or between griseofulvin and ketoconazole, although the trials were generally small. Two trials showed that terbinafine and itraconazole were effective compared with placebo: terbinafine 31 participants, RR.

Freshwater Fungal Infections. Full Text Available Fungal infections as a result of freshwater exposure or trauma are fortunately rare. Etiologic agents are varied, but commonly include filamentous fungi and Candida. This narrative review describes various sources of potential freshwater fungal exposure and the diseases that may result, including fungal keratitis, acute otitis externa and tinea pedis, as well as rare deep soft tissue or bone infections and pulmonary or central nervous system infections following traumatic freshwater exposure during natural disasters or near-drowning episodes.

Fungal etiology should be suspected in appropriate scenarios when bacterial cultures or molecular tests are normal or when the infection worsens or fails to resolve with appropriate antibacterial therapy.

Fungal Skin Infections. Diagnosis Skin scrapings or cultures Doctors may suspect a fungal infection when they The Fungal Biome of the Oral Cavity. Organisms residing in the oral cavity oral microbiota contribute to health and disease, and influence diseases like gingivitis, periodontitis, and oral candidiasis the most common oral complication of HIV- infection. These organisms are also associated with cancer and other systemic diseases including upper respiratory infections. There is limited knowledge regarding how oral microbes interact together and influence the host immune system.

Characterizing the oral microbial community oral microbiota in health and disease represents a critical step in gaining insight into various members of this community.

While most of the studies characterizing oral microbiota have focused on bacterial community, there are few encouraging studies characterizing the oral mycobiome the fungal component of the oral microbiota. Our group recently characterized the oral mycobiome in health and disease focusing on HIV. In this chapter we will describe the methods used by our group for characterization of the oral mycobiome. Fungal Wound Infection. David Tribble, acting director of the infectious disease clinical research program at Uniformed Services University of the Health Sciences, discusses fungal wound infections after combat trauma.

Current management of fungal infections. The management of superficial fungal infections differs significantly from the management of systemic fungal infections. Most superficial infections are treated with topical antifungal agents, the choice of agent being determined by the site and extent of the infection and by the causative organism,.

Superficial fungal infections. Superficial fungal infections arise from a pathogen that is restricted to the stratum corneum, with little or no tissue reaction. In this Seminar, three types of infection will be covered: tinea versicolor, piedra, and tinea nigra. Tinea versicolor is common worldwide and is caused by Malassezia spp, which are human saprophytes that sometimes switch from yeast to pathogenic mycelial form.

Malassezia furfur, Malassezia globosa, and Malassezia sympodialis are most closely linked to tinea versicolor. White and black piedra are both common in tropical regions of the world; white piedra is also endemic in temperate climates. Black piedra is caused by Piedraia hortae; white piedra is due to pathogenic species of the Trichosporon genus. Tinea nigra is also common in tropical areas and has been confused with melanoma.

Burden of fungal infections in Senegal. Senegal has a high rate of tuberculosis and a low HIV seropositivity rate and aspergilloma, life-threatening fungal infections , dermatophytosis and mycetoma have been reported in this study. All published epidemiology papers reporting fungal infection rates from Senegal were identified. Where no data existed, we used specific populations at risk and fungal infection frequencies in each to estimate national incidence or prevalence.

We estimate incident cases of chronic pulmonary aspergillosis CPA following TB and prevalence of cases. Asthma prevalence in adults varies from 3. Since , cases of mycetoma were diagnosed. In conclusion, we estimate that 1,, Diagnostic and treatment deficiencies should be rectified to allow epidemiological studies.

Iron is an essential factor for both the growth and virulence of most of microorganisms. As a part of the innate or nutritional immune system, mammals have developed different mechanisms to store and transport this element in order to limit free iron bioavailability.

To survive in this hostile environment, pathogenic fungi have specific uptake systems for host iron sources, one of the most important of which is based on the synthesis of siderophores-soluble, low-molecular-mass, high-affinity iron chelators. The increase in free iron that results from iron-overload conditions is a well-established risk factor for invasive fungal infection IFI such as mucormycosis or aspergillosis.

Therefore, iron chelation may be an appealing therapeutic option for these infections. Nevertheless, deferoxamine -the first approved iron chelator- paradoxically increases the incidence of IFI, as it serves as a xeno-siderophore to Mucorales.

On the contrary, the new oral iron chelators deferiprone and deferasirox have shown to exert a deleterious effect on fungal growth both in vitro and in animal models. The present review focuses on the role of iron metabolism in the pathogenesis of IFI and summarises the preclinical data, as well as the limited clinical experience so far, in the use of new iron chelators as treatment for mucormycosis and invasive aspergillosis. Published by Elsevier Espana. All rights reserved.

Burden of serious fungal infections in Guatemala. Guatemala is a developing country in Central America with a high burden of HIV and endemic fungal infections ; we attempted to estimate the burden of serious fungal infections for the country. A full literature search was done to identify epidemiology papers reporting fungal infections from Guatemala. We used specific populations at risk and fungal infection frequencies in the population to estimate national rates.

The population of Guatemala in was There are an estimated 53, adults with HIV infection , in , most presenting late. The estimated cases of opportunistic fungal infections were: cases of disseminated histoplasmosis, cases of cryptococcal meningitis, cases of Pneumocystis pneumonia, 16, cases of oral candidiasis, and 4, cases of esophageal candidiasis. In the general population, an estimated 5, adult asthmatics have allergic bronchopulmonary aspergillosis ABPA based on a 2.

Amongst 2, pulmonary tuberculosis patients, we estimated a prevalence of for chronic pulmonary aspergillosis in this group, and 1, for all conditions. An estimated , cases of recurrent vulvovaginal candidiasis is likely. Overall, 1. The true fungal infection burden in Guatemala is unknown. Tools and training for improved diagnosis are needed.

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